Nuno Espirito Santo's dismissal comes after Tottenham lost 3-0 at home to Manchester United, their fourth defeat in six Premier League games.
Tottenham are eighth in the Premier League, 10 points off leaders Chelsea, after the 3-0 home defeat to Manchester United on Saturday.
Nuno, 47, signed a two-year contract in June following a protracted search to find Jose Mourinho's successor.
The departure of Nuno, who left Wolves in May after four seasons in charge, means Tottenham are looking for their fourth permanent manager in the last three years.
Source: Sky sports
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